Florence Mwikali Mutua is a Kenyan politician from Busia town. A former member of the National Assembly of Kenya. A former Women representative for Busia county. She was the Women Representative for Busia county for two terms, from August 2013 to August 2022. Under the reign of the fourth president of Kenya, Uhuru Muigai Kenyatta. She served the two terms through Orange Democratic Movement. In the latest Kenyan election, the 2022 general election, she vied for the governor seat though she lost it to Paul Otuoma. Mutua is the only woman to vie for the gubernatorial race in Busia during the 2022 general election. If she had won, she would have become the first woman governor in Busia county.

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